Have you noticed unusual changes in your legs — swelling at night, visible veins, or persistent itching? These issues are often blamed on fatigue or aging. But did you know your legs can be an important indicator of liver health?
Why the Legs?
Gravity: Blood and fluids tend to accumulate more easily in the lower limbs.
Circulation: The liver is essential for protein synthesis and the regulation of portal vein pressure. When liver function declines, it can directly affect blood flow in the legs.
Metabolism: The liver produces proteins that help retain fluid inside blood vessels. When these proteins (especially albumin) decrease, fluid can leak into tissues, causing swelling.
5 Warning Signs on Your Legs That May Signal Liver Problems
1. Swelling (Thighs, Ankles, or Feet)
What it looks like: Shoes feel tight, sock marks remain visible, and when you press the skin, a small dent stays for a few seconds. Swelling usually worsens in the evening.
Liver connection: Damaged liver cells produce less albumin, a key protein that helps maintain fluid balance. Low albumin levels allow fluid to seep into tissues, leading to edema. In addition, portal hypertension (increased pressure in the portal vein) disrupts normal venous return, contributing to swelling.
What they look like: Small red or purple “spider webs” on the ankles, feet, or legs.
Liver connection: These are often seen in chronic liver diseases such as cirrhosis. They result from altered hormone metabolism (especially estrogen) and increased venous pressure.
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