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Combine the Base: In a medium mixing bowl, combine the softened cream cheese, mayonnaise, parmesan cheese, garlic powder, onion powder, salt, and black pepper. Mix with a spatula or hand mixer until smooth and fully incorporated.
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Add Mix-Ins: Gently fold in the chopped artichoke hearts, pickled jalapeños, and shredded mozzarella cheese until everything is evenly distributed throughout the creamy base.
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Chill: For the best flavor, cover the bowl and refrigerate the dip for at least 1 hour, or ideally overnight. This allows the flavors to meld together perfectly.
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Serve & Enjoy! Remove the dip from the refrigerator about 15 minutes before serving to let it soften slightly. Serve with tortilla chips, crispy bread slices, crackers, or fresh vegetable sticks.