Researchers at Kyoto University Hospital have developed a drug that works by targeting a protein called USAG-1, which suppresses tooth growth. By blocking this protein, dormant tooth-forming buds can be reactivated—essentially allowing the body to grow new teeth.
Animal studies in mice and ferrets showed promising results, with subjects successfully regrowing lost teeth. Encouraged by these outcomes, researchers began the first human clinical trials in September 2024.
Why This Breakthrough Matters
Tooth loss affects millions worldwide due to decay, gum disease, injury, or aging. Current treatments like implants and dentures are effective but come with challenges such as:
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High cost and accessibility issues
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Risk of infection or rejection
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Lack of natural tooth function and sensation
If this treatment proves successful, it could transform dentistry by offering a biological, permanent solution—your body simply regrows real teeth.
Other Innovations in Dental Regeneration
The excitement doesn’t stop in Japan. Around the world, scientists are exploring new ways to repair and regenerate teeth:
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Keratin-based enamel repair: Researchers in the UK are developing eco-friendly dental treatments made from sheep’s wool and human hair that can repair weakened enamel. This may soon appear in toothpaste and gels.
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Bioengineered teeth: Scientists at Tufts University have successfully grown teeth in pigs using hybrid cell technology, paving the way for human applications in the future.
When Could Tooth Regrowth Be Available?
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