A labor drug helps clean the brain: hopes for Alzheimer’s and Parkinson’s Facebook4 X copy link More

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The research was conducted by an international team led by Professor Douglas Kelley from the Department of Mechanical Engineering at the University of Rochester, in collaboration with the Center for Translational Neuromedicine – Division of Glial Diseases and Therapeutics. The results were published in Nature Communications

🧪 How prostaglandin F2α works in the brain

The glymphatic system, discovered in 2012, is responsible for removing waste from the brain through cerebrospinal fluid. As we age, this system loses efficiency, leading to the accumulation of toxic proteins such as beta-amyloid and alpha-synuclein, which are implicated in Alzheimer’s and Parkinson’s disease, respectively.

In aged mice treated with PGF2α, the glymphatic system showed significant improvement, with increased cerebrospinal fluid flow and a reduction in toxic waste.

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